Affective state-dependent changes in the brain functional network in major depressive disorder 

Chang-hyun Park,1 Sheng-Min Wang,2 Hae-Kook Lee,2 Yong-Sil Kweon,2 Chung Tai Lee,2 Ki-Tae Kim,3 Young-Joo Kim,3 and Kyoung-Uk Lee2 

In major depressive disorder (MDD), as a network-level disease, the pathophysiology would be displayed to a wide extent over the brain. Moreover, the network-wide changes could be dependent on the context of affective processing. In this study, we sought affective state-dependent changes of the brain functional network by applying a graph-theoretical approach to functional magnetic resonance imaging data acquired in 13 patients with MDD and 12 healthy controls who were exposed to video clips inducing the negative, neutral or positive affective state. For each affective condition, a group-wise brain functional network was constructed based on partial correlation of mean activity across subjects between brain areas. Network parameters, global and local efficiencies, were measured from the brain functional network. Compared with controls , patients brain functional network shifted to the regular network in the topological architecture, showing decreased global efficiency and increased local efficiency, during negative and neutral affective processing. Further, the shift to the regular network in patients was most evident during negative affective processing. MDD is proposed to provoke widespread changes across the whole brain in an affective state-dependent manner, specifically in the negative affective state. 

Keywords: major depressive disorder; fMRI; graph-theoretical analysis; affective processing

The whole paper 
http://pan.baidu.com/s/1hqqSEZ6